[ad_1]
January 31, 2023
Read in 2 minutes
Source/Disclosure
The issuer:
Disclosure:
The study authors did not report relevant financial disclosures. Santos has received consultancy, research and speaking fees from Abbott, Ache, Amgen, Amryt, AstraZeneca, Biolab, Esperion, Eli Lilly, Getz Pharma, Kowa, Libbs, Novo Nordisk, Novartis, Merck, Pfizer, PTC Therapeutics and Sanofi reported that
A healthy lifestyle was associated with reduced CVD risk in adults with familial hypercholesterolemia, regardless of familial hypercholesterolemia mutational status, researchers reported.
“DNA is not destiny. Not deterministic for familial hypercholesterolemia (FH).” Hayato Dr. Tada, An assistant professor of cardiology at the Kanazawa University Graduate School of Medicine told Helio: “Our study shows that a healthy lifestyle is associated with a reduced risk of CVD in him, regardless of his FH mutational status, and that his clinical and genetic diagnosis as FH It suggests that the risk of CVD is not deterministic.”
A healthy lifestyle was associated with reduced CVD risk in adults with FH, regardless of FH mutation status.
Source: Adobe Stock
“Inherited risk can be reduced”
Hayato Tada
In a retrospective study, Tada et al. analyzed data from 961 adults diagnosed with FH using the 2017 Japanese Atherosclerosis Society criteria between 1990 and 2000 at Kanazawa University Hospital. Did. The average age of patients he was 52 years. 46.7% were male, 30.6% had a history of his CVD, and 699 were positive for his FH mutation. Researchers assessed the interaction of genotype and lifestyle with the occurrence of serious adverse cardiovascular events such as cardiovascular death, myocardial infarction, unstable angina, and coronary revascularization . A healthy lifestyle was defined as a healthy eating pattern, regular exercise, non-smoking, and lack of obesity, all he assessed on four questionnaires.
The survey results are JACC: Asia.
During a median follow-up of 12.6 years, researchers observed 179 serious adverse CV events.
Apart from classical risk factors, FH mutation had a HR of 2.73 (95% CI, 1.03-4.43; 95% CI, 1.03-4.43; P = .02), higher healthy lifestyle scores were inversely related (HR per point = 0.69; 95% CI, 0.4–0.98; P = .033). The estimated risk of developing CAD by age 75 years varies by lifestyle, ranging from 21% in non-carriers with a favorable lifestyle to 32.1% in non-carriers with an unfavorable lifestyle. It ranges from 29% of carriers with the disease to 55.4% of carriers. unfavorable lifestyle.
The researchers say the data suggest that clinical and genetic diagnosis of FH is not definitive for CVD risk.
“In fact, we are pleased to discover that a healthy lifestyle can reduce genetic risk,” the researchers wrote.
Tada told Healio that more research is needed to clarify which factors, especially when, should be considered for lifestyle interventions in this high-risk group of patients.
Smoking cessation is the ‘most protective factor’
Raul D. Santos
In a related editorial, Raul D. Santos MDs, PhDs, MScs, A professor at the Heart Institute of the University of Sao Paulo School of Medicine noted that smoking cessation was the strongest protective factor against major adverse cardiovascular events, adding that the higher the healthy lifestyle score, the lower the risk. Prevention of atherosclerotic CVD in this high-risk population. ”
“Furthermore, physical activity and diet may be crucial in regulating proatherogenic mechanisms and reducing the ASCVD burden in FH,” Santos wrote.
reference:
For more information:
Hayato Dr. Tada,doctorate, Please contact ht240z@sa3.so-net.ne.jp. Twitter: @hayato_tada_ku.
[ad_2]
Source link
